Design and in vitro Evaluation of Gastroretentive Floating Drug Delivery System of Rosigilitazone Maleate

Rosigilitazone maleate is an anti-diabetic agent is used in the management of Type-II diabetes mellitus. The present investigation concerns the development of the sustained release floating matrix tablets which are designed to exhibit a prolonged gastric residence time and controlling the drug release from the dosage form. This system is useful particularly for achieving controlled plasma level as well as improving bioavailability of the drug. The formulated floating tablets containing 10mg Rosigilitazone maleate were developed using Hydroxyl propyl methyl cellulose (HPMC) and different additives.The formulated tablets obtained by the direct compression method, followed by optimization of the evaluated parameters were employed to get the final optimized formulation. The resulting formulations indicated optimum hardness, uniform thickness, consistent weight uniformity and low friability. The formulated tablets were able to continuously float over the stimulated gastric fluid for 24hrs. The dissolution studies showed that formulations F4, F6 and F7 exhibited sustained drug release pattern. Drug release kinetics was evaluated using the krosmeyer peppas model and found to be governed by Fickian diffusion. The floating behavior of the designed tablets could be successfully combined with accurate control of the drug release patterns.